Recruitment and membrane interactions of host cell proteins during attachment of enteropathogenic and enterohaemorrhagic Escherichia coli
نویسندگان
چکیده
منابع مشابه
A comparison of enteropathogenic and enterohaemorrhagic Escherichia coli pathogenesis.
This review covers enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC) infections, focusing on differences in their virulence factors and regulation. While Shiga-toxin expression from integrated bacteriophages sets EHEC apart from EPEC, EHEC infections often originate from asymptomatic carriage in ruminants whereas human EPEC are considered to be overt pathogens and m...
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A key strategy in microbial pathogenesis is the subversion of the first line of cellular immune defences presented by professional phagocytes. Enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC respectively) remain extracellular while colonizing the gut mucosa by attaching and effacing mechanism. EPEC use the type three secretion system effector protein EspF to prevent thei...
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The flagellar apparatus consists of components that function as a type III secretion system (TTSS). Enteropathogenic and enterohaemorrhagic E. coli (EPEC and EHEC, respectively) produce an additional TTSS, which is involved in virulence via the translocation of effector proteins into infected host cells. This system is encoded by the locus of enterocyte effacement (LEE). The authors observed th...
متن کاملInteractions and predicted host membrane topology of the enteropathogenic Escherichia coli translocator protein EspB.
Type 3 secretion systems (T3SSs) are critical for the virulence of numerous deadly Gram-negative pathogens. T3SS translocator proteins are required for effector proteins to traverse the host cell membrane and perturb cell function. Translocator proteins include two hydrophobic proteins, represented in enteropathogenic Escherichia coli (EPEC) by EspB and EspD, which are thought to interact and f...
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Charles Darkoh1,2 and Herbert L. DuPont1,2,3,4,5 1Graduate School of Biomedical Sciences, Molecular Pathology Program, The University of Texas; 2The University of Texas School of Public Health, Center for Infectious Diseases; 3Department of Internal Medicine, The University of Texas Medical School; 4Internal Medicine Service, St. Luke's Episcopal Hospital; and 5Department of Medicine, Baylor Co...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2012
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20120533